Article
Treatment-influenced associations of PML-RARα mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia.
Blood - 6 Sept 2012
Gallagher Robert E, Moser Barry K, Racevskis Janis, Poiré Xavier, Bloomfield Clara D, Carroll Andrew J, Ketterling Rhett P, Roulston Diane, Schachter-Tokarz Esther, Zhou Da-Cheng, Chen I-Ming L, Harvey Richard, Koval Greg, Sher Dorie A, Feusner James H, Tallman Martin S, Larson Richard A, Powell Bayard L, Appelbaum Frederick R, Paietta Elisabeth, Willman Cheryl L, Stock Wendy
Abstract excerpt
Mutations in the all-trans retinoic acid (ATRA)-targeted ligand binding domain of PML-RARα (PRα/LBD+) have been implicated in the passive selection of ATRA-resistant acute promyelocytic leukemia clones leading to disease relapse. Among 45 relapse patients from the ATRA/chemotherapy arm of intergr...
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