Article
Distribution of events of positive selection and population differentiation in a metabolic pathway: the case of asparagine N-glycosylation.
BMC evolutionary biology - 25 Jun 2012
Dall'Olio Giovanni Marco, Laayouni Hafid, Luisi Pierre, Sikora Martin, Montanucci Ludovica, Bertranpetit Jaume
Abstract excerpt
BACKGROUND: Asparagine N-Glycosylation is one of the most important forms of protein post-translational modification in eukaryotes. This metabolic pathway can be subdivided into two parts: an upstream sub-pathway required for achieving proper folding for most of the proteins synthesized in the secretory pathway, and a downstream sub-pathway required to give variability to trans-membrane proteins, and involved in...
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