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Zonulin, regulation of tight junctions, and autoimmune diseases

25 Jun 2012

Abstract excerpt

Recent studies indicate that besides digestion and absorption of nutrients and water and electrolytes homeostasis, another key function of the intestine is to regulate the trafficking of environmental antigens across the host mucosal barrier. Intestinal tight junctions (TJs) create gradients for the optimal absorption and transport of nutrients and control the balance between tolerance and immunity to nonself...

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PMID: 22731712
DOI: 10.1111/j.1749-6632.2012.06538.x

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