Article
Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives.
Diabetes - 1 May 2006
Sapone Anna, de Magistris Laura, Pietzak Michelle, Clemente Maria G, Tripathi Amit, Cucca Francesco, Lampis Rosanna, Kryszak Deborah, Cartenì Maria, Generoso Maddalena, Iafusco Dario, Prisco Francesco, Laghi Francesca, Riegler Gabriele, Carratu Romano, Counts Debra, Fasano Alessio
Abstract excerpt
Zonulin, a protein that modulates intestinal permeability, is upregulated in several autoimmune diseases and is involved in the pathogenesis of autoimmune diabetes in the BB/Wor animal model of the disease. To verify the association between serum zonulin levels and in vivo intestinal permeability in patients with type 1 diabetes, both parameters were investigated in different stages of the autoimmune process....
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