Article
Oxidative phosphorylation dysfunction modulates expression of extracellular matrix--remodeling genes and invasion.
Carcinogenesis - 1 Mar 2006
van Waveren Corina, Sun Yubo, Cheung Herman S, Moraes Carlos T
Abstract excerpt
A number of recent studies suggest that mitochondrial function is a player in tumor development and progression. In this study, we have used gene expression arrays to examine transcriptional differences between oxidative phosphorylation (OXPHOS)-competent and OXPHOS-impaired human osteosarcoma cells. Genes associated with extracellular matrix remodeling, including members of the matrix metalloproteinases (MMPs)...
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