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Article

Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET study.

The Journal of clinical endocrinology and metabolism - 1 Sept 2012

Joffe Hadine, Deckersbach Thilo, Lin Nancy U, Makris Nikos, Skaar Todd C, Rauch Scott L, Dougherty Darin D, Hall Janet E

Abstract excerpt

CONTEXT: Hot flashes are a common side effect of adjuvant endocrine therapies (AET; leuprolide, tamoxifen, aromatase inhibitors) that reduce quality of life and treatment adherence in breast cancer patients. Because hot flashes affect only some women, preexisting neurobiological traits might predispose to their development. Previous studies have implicated the insula during the perception of hot flashes and the...

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Share to Body Temperature Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22723326
DOI: 10.1210/jc.2012-1413
PMCID: PMC3791433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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