Article
Modulation of membrane phenotype, matrix adhesion and microinvasiveness of metastatic tumour cells by HUdR.
Cell biochemistry and function - 1 Oct 1990
Timár J, Pogány G, Balázs M, Szöllösi J, Ladányi A, Oláh J, Timár F, Lapis K, Jeney A
Abstract excerpt
The effect of HUdR, proved to be anti-metastatic in vivo, was studied in vitro on cell proliferation, nucleoside uptake, membrane fluidity, expression of galactosylated glycans and proteoglycans in metastatic HM tumour cells. The observed increase in membrane fluidity and the suppression of nucleoside transport were early events of the HUdR action followed by decrease of galactosylated glycan and HSPG expression....
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