Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.

PLoS neglected tropical diseases - 1 Jan 2012

Giacani Lorenzo, Chattopadhyay Sujay, Centurion-Lara Arturo, Jeffrey Brendan M, Le Hoavan T, Molini Barbara J, Lukehart Sheila A, Sokurenko Evgeni V, Rockey Daniel D

Abstract excerpt

In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical. Between these strains, significant differences are found in expression of, and antibody responses to some candidate virulen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Bacterial

Share to Rabbits

Share to Selection, Genetic

Share to Sequence Homology, Nucleic Acid

Share to Syphilis

Share to Treponema pallidum

Source

Open in PubMed Open full text

Identifiers

PMID: 22720110
DOI: 10.1371/journal.pntd.0001698
PMCID: PMC3373638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22720110-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.PMID 22720110Read ↗

Complete genome sequence of Treponema pallidum strain DAL-1Semantic proximity Read ↗

Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays.Semantic proximity Read ↗

Clonal isolates of Treponema pallidum subsp. pallidum Nichols provide evidence for the occurrence of microevolution during experimental rabbit infection and in vitro cultureSemantic proximity Read ↗

Syphilis-causing strains belong to separate SS14-like or Nichols-like groups as defined by multilocus analysis of 19 Treponema pallidum strains.Semantic proximity Read ↗

Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete.Semantic proximity Read ↗

Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates.Semantic proximity Read ↗

Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes.Semantic proximity Read ↗

Phylogenetic and genetic characterization of Treponema pallidum strains from syphilis patients in Japan by whole-genome sequence analysis from global perspectives.Semantic proximity Read ↗

Genome sequencing of 196 <i>Treponema pallidum</i> strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in MadagascarSemantic proximity Read ↗

Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilisSemantic proximity Read ↗

Sequence variation of rare outer membrane protein β-barrel domains in clinical strains provides insights into the evolution of <i>Treponema pallidum</i> subsp. <i>pallidum</i> , the syphilis spirocheteSemantic proximity Read ↗

<i>Treponema pallidum</i> subsp. <i>pallidum</i> genetic population structure and relevance to syphilis prevention and treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.