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Article

JAK2V617F mutation and allele burden are associated with distinct clinical and morphological subtypes in patients with essential thrombocythaemia

20 Jun 2012

Abstract excerpt

Essential thrombocythaemia (ET) is a chronic myeloproliferative neoplasm (MPN) that primarily involves the megakaryocytic lineage.1 The JAK2V617F mutation has been detected in 50–60% of ETs, and homozygous mutation in only 5%.2 JAK2V617F mutation has been associated with a polycythaemia vera (PV)-like phenotype3 and increased risk of thrombosis,4 especially in homozygous patients.5 Increasing mutant allele load...

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Identifiers

PMID: 22718845
DOI: 10.1136/jclinpath-2012-200804

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