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Antitumor effect of baicalin from the Scutellaria baicalensis radix extract in B-acute lymphoblastic leukemia with different chromosomal rearrangements

24 Dec 2019

Abstract excerpt

Acute B-lymphoblastic leukemia (B-ALL) is the most common hematologic malignancy in children. Many cases of B-ALL harbor chromosomal translocations which are often critical determinants of prognosis. Most of them represent altered transcription factors that impact gene transcription or enhance signaling. B-ALLs harboring the mixed-lineage leukemia 1 ( MLL1 ) gene rearrangements represent aggressive, high-risk...

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PMID: 31881375
DOI: 10.1016/j.intimp.2019.106114

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