Article
In vitro replication phenotype of a novel (-1G) hepatitis B virus variant associated with HIV co-infection.
Journal of medical virology - 1 Aug 2012
Cabuang Liza M, Shaw Tim, Littlejohn Margaret, Colledge Danni, Sozzi Vitini, Soppe Sally, Warner Nadia, Thompson Alex, Preiss Scott, Lam Natasha, Walsh Renae, Lewin Sharon R, Thio Chloe L, Matthews Gail, Locarnini Stephen A, Revill Peter A
Abstract excerpt
The -1G mutant HBV is more prevalent in individuals co-infected with HIV/HBV than in individuals infected with HBV alone and in some cases is the dominant virus in circulation. This mutant is created by the deletion of a dGMP (-1G) from the guanine rich homopolymer sequence located at nts 2,085-2,090 (numbering from EcoRI site as position 1) in the HBV core gene. This deletion causes a frameshift generating a...
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