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Article

LRRTM3 is dispensable for amyloid-β production in mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Laakso Tiina, Muggalla Pranuthi, Kysenius Kai, Laurén Juha, Paatero Anja, Huttunen Henri J, Airaksinen Matti S

Abstract excerpt

Neuronal LRRTM3 (leucine-rich repeat transmembrane 3) protein has been reported to promote amyloid-β protein precursor (AβPP) processing and LRRTM3 is a candidate gene in late-onset Alzheimer's disease. To address the role of LRRTM3 in AβPP processing and amyloid-β (Aβ) production in vivo, we ana...

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Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22710909
DOI: 10.3233/JAD-2012-120193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22710909-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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LRRTM3 is dispensable for amyloid-β production in mice.PMID 22710909Read ↗

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LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).Semantic proximity Read ↗

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