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Borrelia burgdorferi Harbors a Transport System Essential for Purine Salvage and Mammalian Infection

19 Jun 2012

Abstract excerpt

Borrelia burgdorferi is the tick-borne bacterium that causes the multistage inflammatory disease Lyme disease. B. burgdorferi has a reduced genome and lacks the enzymes required for de novo synthesis of purines for synthesis of RNA and DNA. Therefore, this obligate pathogen is dependent upon the tick vector and mammalian host environments for salvage of purine bases for nucleic acid biosynthesis. This pathway is...

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PMID: 22710875
DOI: 10.1128/iai.00514-12

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