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Article

Plasmid location of Borrelia purine biosynthesis gene homologs

1 Nov 1994

Abstract excerpt

The Lyme disease spirochete Borrelia burgdorferi must survive in both its tick vector and its mammalian host to be maintained in nature. We have identified the B. burgdorferi guaA gene encoding GMP synthetase, an enzyme involved in de novo purine biosynthesis that is important for the survival of bacteria in mammalian blood. This gene encodes a functional product that will complement an Escherichia coli GMP...

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PMID: 7961392
DOI: 10.1128/jb.176.21.6427-6432.1994

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