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Article

Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells.

Oncology reports - 1 Sept 2012

Miyake Naomi, Chikumi Hiroki, Takata Miyako, Nakamoto Masaki, Igishi Tadashi, Shimizu Eiji

Abstract excerpt

The mammalian target of rapamycin (mTOR) is a key kinase acting downstream of growth factor receptor PI3K and AKT signaling, leading to processes resulting in increased cell size and proliferation through translation control. Rapamycin, a specific inhibitor of mTOR, results predominately in G1 cell cycle arrest through translation control and occasionally, cell...

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Source

Identifiers

PMID: 22710790
DOI: 10.3892/or.2012.1855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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