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Article

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

Cell - 25 Mar 2005

Beuvink Iwan, Boulay Anne, Fumagalli Stefano, Zilbermann Frederic, Ruetz Stephan, O'Reilly Terence, Natt Francois, Hall Jonathan, Lane Heidi A, Thomas George

Abstract excerpt

Although DNA damaging agents have revolutionized chemotherapy against solid tumors, a narrow therapeutic window combined with severe side effects has limited their broader use. Here we show that RAD001 (everolimus), a rapamycin derivative, dramatically enhances cisplatin-induced apoptosis in wild-type p53, but not mutant p53 tumor cells. The use of isogenic tumor cell lines expressing either wild-type mTOR cDNA...

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Identifiers

PMID: 15797377
DOI: 10.1016/j.cell.2004.12.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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