Article
Drug-drug interaction of rabeprazole and clopidogrel in healthy Chinese volunteers.
European journal of clinical pharmacology - 1 Feb 2013
Wu Jia, Jia Li-Tao, Shao Li-Ming, Chen Jia-Min, Zhong Dan-Dan, Xu Song, Cai Jian-Ting
Abstract excerpt
PURPOSE: This study was aimed to determine the impact of rabeprazole (RBRZ) on the antiplatelet efficacy of clopidogrel (CPG) in healthy Chinese volunteers, and further to predict the effect of CYP2C19 genetic polymorphism on the efficacy of rabeprazole and clopidogrel. METHODS: The open-label, two period cross-over study was conducted in 20 healthy Chinese subjects with different CYP2C19 genotypes receiving...
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