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Article

MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Mar 2018

Ferrucci Francesca, Ciaccio Roberto, Monticelli Sara, Pigini Paolo, di Giacomo Simone, Purgato Stefania, Erriquez Daniela, Bernardoni Roberto, Norris Murray, Haber Michelle, Milazzo Giorgio, Perini Giovanni

Abstract excerpt

Childhood neuroblastoma, a disease of the sympathetic nervous system, is the most common solid tumour of infancy, remarkably refractory to therapeutic treatments. One of the most powerful independent prognostic indicators for this disease is the amplification of the MYCN oncogene, which occurs at high levels in approximately 25% of neuroblastomas. Interestingly, amplification and not just expression of MYCN has a...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29408445
DOI: 10.1016/j.bbagrm.2018.01.007

Genes

MYCN
MAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.PMID 29408445Read ↗

Neuroblastoma and MYCN.Semantic proximity Read ↗

MYCN in Neuroblastoma: “Old Wine into New Wineskins”Semantic proximity Read ↗

Phosphorylation of MYCN and MAX by PAK family kinases is a novel tumor-suppressor mechanism in neuroblastoma with potential therapeutic implicationsSemantic proximity Read ↗

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer AmplificationSemantic proximity Read ↗

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastomaSemantic proximity Read ↗

Global MYCN Transcription Factor Binding Analysis in Neuroblastoma Reveals Association with Distinct E-Box Motifs and Regions of DNA HypermethylationSemantic proximity Read ↗

The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic PotentialSemantic proximity Read ↗

High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastomaSemantic proximity Read ↗

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MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formationSemantic proximity Read ↗

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma FormationSemantic proximity Read ↗

MAX and MYC: A Heritable BreakupSemantic proximity Read ↗

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