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Article

The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B.

Archives of biochemistry and biophysics - 1 Sept 2012

Brandão Tiago A S, Johnson Sean J, Hengge Alvan C

Abstract excerpt

The movement of a conserved protein loop (the WPD-loop) is important in catalysis by protein tyrosine phosphatases (PTPs). Using kinetics, isotope effects, and X-ray crystallography, the different effects arising from mutation of the conserved tryptophan in the WPD-loop were compared in two PTPs, the human PTP1B, and the bacterial YopH from Yersinia. Mutation of the conserved tryptophan in the WPD-loop to...

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Share to Bacterial Outer Membrane Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22698963
DOI: 10.1016/j.abb.2012.06.002
PMCID: PMC3422214

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