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Sirt1, p53, and p38(MAPK) are crucial regulators of detrimental phenotypes of embryonic stem cells with Max expression ablation.

Stem cells (Dayton, Ohio) - 1 Aug 2012

Hishida Tomoaki, Nozaki Yuriko, Nakachi Yutaka, Mizuno Yosuke, Iseki Hiroyoshi, Katano Miyuki, Kamon Masayoshi, Hirasaki Masataka, Nishimoto Masazumi, Okazaki Yasushi, Okuda Akihiko

Abstract excerpt

c-Myc participates in diverse cellular processes including cell cycle control, tumorigenic transformation, and reprogramming of somatic cells to induced pluripotent cells. c-Myc is also an important regulator of self-renewal and pluripotency of embryonic stem cells (ESCs). We recently demonstrated that loss of the Max gene, encoding the best characterized partner for all Myc family proteins, causes loss of the...

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PMID: 22696478
DOI: 10.1002/stem.1147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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