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Article

A histone fold TAF octamer within the yeast TFIID transcriptional coactivator.

Nature structural biology - 1 Aug 2001

Selleck W, Howley R, Fang Q, Podolny V, Fried M G, Buratowski S, Tan S

Abstract excerpt

Gene activity in a eukaryotic cell is regulated by accessory factors to RNA polymerase II, which include the general transcription factor complex TFIID, composed of TBP and TBP-associated factors (TAFs). Three TAFs that contain histone fold motifs (yTAF17, yTAF60 and yTAF61) are critical for transcriptional regulation in the yeast Saccharomyces cerevisiae and are found in both TFIID and SAGA, a multicomponent...

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Share to Macromolecular Substances
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11473260
DOI: 10.1038/90408

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A histone fold TAF octamer within the yeast TFIID transcriptional coactivator.PMID 11473260Read ↗

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Histone-like TAFs are essential for transcription in vivo.Semantic proximity Read ↗

A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression.Semantic proximity Read ↗

yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complex.Semantic proximity Read ↗

Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation.Semantic proximity Read ↗

Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.Semantic proximity Read ↗

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The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.Semantic proximity Read ↗

The yeast FACT complex has a role in transcriptional initiation.Semantic proximity Read ↗

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