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Article

Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia

9 Aug 2006

Abstract excerpt

The choice of adeno-associated virus serotypes for clinical applications is influenced by the animal model and model system used to evaluate various serotypes. In the present study, we sought to compare the biologic properties of rAAV2/1, rAAV2/2, and rAAV2/5 transduction in polarized human airway epithelia using viruses purified by a newly developed common column chromatography method. Results demonstrated that...

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PMID: 16899463
DOI: 10.1074/jbc.m604099200

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