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Article

Basis for early and preferential selection of the E138K mutation in HIV-1 reverse transcriptase.

Antimicrobial agents and chemotherapy - 1 Oct 2013

McCallum Matthew, Oliveira Maureen, Ibanescu Ruxandra-Ilinca, Kramer Victor G, Moisi Daniela, Asahchop Eugene L, Brenner Bluma G, Harrigan P Richard, Xu Hongtao, Wainberg Mark A

Abstract excerpt

E138K, a G→A mutation in HIV-1 reverse transcriptase (RT), is preferentially selected by etravirine (ETR) and rilpivirine over other substitutions at position E138 that offer greater drug resistance. We hypothesized that there was a mutational bias for the E138K substitution and designed an allele-specific PCR to monitor the emergence of E138A/G/K/Q/R/V during ETR selection experiments. We also performed...

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Identifiers

PMID: 23856772
DOI: 10.1128/AAC.01029-13
PMCID: PMC3811420

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