Article
Genetic influences on right ventricular systolic pressure (RVSP) in chronic obstructive pulmonary disease (COPD).
BMC pulmonary medicine - 13 Jun 2012
Shaw Janet G, Dent Annette G, Passmore Linda H, Burstow Darryl J, Bowman Rayleen V, Zimmerman Paul V, Fong Kwun M, Yang Ian A
Abstract excerpt
BACKGROUND: Pulmonary hypertension (PH) is a complication of chronic obstructive pulmonary disease (COPD). This study examined genetic variations in mediators of vascular remodelling and their association with PH in patients with COPD. In patients with COPD, we genotyped 7 SNPs in 6 candidate PH genes (NOS3, ACE, EDN1, PTGIS, SLC6A4, VEGFA). We tested for association with right ventricular systolic pressure...
Topics
- Aged
- Cohort Studies
- Female
- Forced Expiratory Volume
- Genetic Markers
- Genotype
- Genotyping Techniques
- Humans
- Hypertension, Pulmonary
- Linear Models
- Male
- Minisatellite Repeats
- Nitric Oxide Synthase Type III