Article
The influence of HLA on HIV-associated neurocognitive impairment in Anhui, China.
PloS one - 1 Jan 2012
Schrier Rachel D, Gupta Saurabh, Riggs Patricia, Cysique Lucette A, Letendre Scott, Jin Hua, Spector Stephen A, Singh Kumud K, Wolfson Tanya, Wu Zunyou, Hong Kun Xue, Yu Xin, Shi Chuan, Heaton Robert K
Abstract excerpt
BACKGROUND: HLA-DR*04 was identified as a predictor of HIV-Associated neurocognitive disorder (HAND), low CD4 T-cell responses to HIV, and low plasma HIV RNA levels in a U.S. cohort. We hypothesized that low CD4 T-cell activation leads to poor immune control of HIV in the CNS, predisposing to HAND, but also provided fewer target (activated CD4 T-cells) for HIV replication. To assess the consistency of these HLA...
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