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Article

Evolution of a new function in an esterase: simple amino acid substitutions enable the activity present in the larger paralog, BioH.

Protein engineering, design & selection : PEDS - 1 Aug 2012

Flores Humberto, Lin Steven, Contreras-Ferrat Gabriel, Cronan John E, Morett Enrique

Abstract excerpt

Gene duplication and divergence are essential processes for the evolution of new activities. Divergence may be gradual, involving simple amino acid residue substitutions, or drastic, such that larger structural elements are inserted, deleted or rearranged. Vast protein sequence comparisons, supported by some experimental evidence, argue that large structural modifications have been necessary for certain catalytic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22691705
DOI: 10.1093/protein/gzs035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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