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Article

Indication for joint replacement and glutathione s-transferases M1 and T1 genotypes.

Journal of toxicology and environmental health. Part A - 1 Jan 2012

Klein Torsten, Selinski Silvia, Blaszkewicz Meinolf, Hengstler Jan G, Golka Klaus

Abstract excerpt

In most patients with osteoarthritis (OA), therapy-resistant pain is the indication for hip or knee replacement. Glutathione S-transferases, particularly glutathione S-transferase M1 (GSTM1), are involved in metabolism of highly reactive metabolites that may be generated by inflammatory processes. In total, 148 patients with indication for hip or knee replacement and 129 patients of the same hospital without...

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Source

Identifiers

PMID: 22686321
DOI: 10.1080/15287394.2012.675313

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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