Article
Impact of low-level fluoroquinolone resistance genes qnrA1, qnrB19 and qnrS1 on ciprofloxacin treatment of isogenic Escherichia coli strains in a murine urinary tract infection model.
The Journal of antimicrobial chemotherapy - 1 Oct 2012
Jakobsen Lotte, Cattoir Vincent, Jensen Klaus S, Hammerum Anette M, Nordmann Patrice, Frimodt-Møller Niels
Abstract excerpt
OBJECTIVES: To study the impact of qnrA1, qnrB19 and qnrS1 on the ciprofloxacin treatment of urinary tract infection (UTI). METHODS: From a wild-type (wt) Escherichia coli UTI isolate, three isogenic strains were constructed carrying low-level ciprofloxacin resistance genes qnrA1, qnrB19 or qnrS1 (ciprofloxacin MIC range: 0.19-0.38 mg/L). Time-kill studies were performed for all four isogenic strains at the...
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