Article
Urinary Tract Physiological Conditions Promote Ciprofloxacin Resistance in Low-Level-Quinolone-Resistant Escherichia coli.
Antimicrobial agents and chemotherapy - 1 Jul 2016
Martín-Gutiérrez Guillermo, Rodríguez-Beltrán Jerónimo, Rodríguez-Martínez José Manuel, Costas Coloma, Aznar Javier, Pascual Álvaro, Blázquez Jesús
Abstract excerpt
Escherichia coli isolates carrying chromosomally encoded low-level-quinolone-resistant (LLQR) determinants are frequently found in urinary tract infections (UTIs). LLQR mutations are considered the first step in the evolutionary pathway producing high-level fluoroquinolone resistance. Therefore, their evolution and dissemination might influence the outcome of fluoroquinolone treatments of UTI. Previous studies...
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