Article
Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα.
Gut - 1 Jul 2013
Swan Caroline, Duroudier Nathalie P, Campbell Eugene, Zaitoun Abed, Hastings Margaret, Dukes George E, Cox Joanne, Kelly Fiona M, Wilde Jonathan, Lennon Mark G, Neal Keith R, Whorwell Peter J, Hall Ian P, Spiller Robin C
Abstract excerpt
OBJECTIVES: The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms. The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which closely resembles PI-IBS. DESIGN: Part 1: 25 healthy volunteers (HVs), 21 patients 6 months after Campylobacter jejuni...
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