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Kaposi's Sarcoma-Associated Herpesvirus ORF54/dUTPase Downregulates a Ligand for the NK Activating Receptor NKp44

7 Jun 2012

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) establishes long-term latent infection in humans and can cause cancers in endothelial and B cells. A functioning immune system is vital for restricting viral proliferation and preventing KSHV-dependent neoplasms. While natural killer (NK) lymphocytes are known to target virus-infected cells for destruction, their importance in the anti-KSHV immune response is not...

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PMID: 22674989
DOI: 10.1128/jvi.00252-12

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