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Article

Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus.

Cell host & microbe - 13 Nov 2008

Lagos Dimitrios, Vart Richard James, Gratrix Fiona, Westrop Samantha Jane, Emuss Victoria, Wong Ping-Pui, Robey Rebecca, Imami Nesrina, Bower Mark, Gotch Frances, Boshoff Chris

Abstract excerpt

The involvement of Toll-like receptor 4 (TLR4) in immunity against human herpesviruses has not been previously demonstrated. We show that infection of endothelial cells with Kaposi sarcoma herpesvirus (KSHV), a human oncogenic virus, leads to rapid suppression of TLR4 expression. This is a mechanism of immune escape as TLR4 mediates innate immunity against KSHV. In vitro, cells lacking TLR4 are more susceptible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 8, Human

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Source

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Identifiers

PMID: 18996347
DOI: 10.1016/j.chom.2008.09.012
PMCID: PMC2698447

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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