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Article

Kaposi's Sarcoma-Associated Herpesvirus Encodes a Viral Deubiquitinase

29 Jul 2009

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically linked to Kaposi's sarcoma, primary effusion lymphomas, and multicentric Castleman's disease. Like other herpesviruses, KSHV can exist in either a lytic or a latent phase during its life cycle. We report that the lytic protein encoded by KSHV open reading frame 64 (Orf64) is a viral deubiquitinase (DUB) enzyme capable of deubiquitinating cellular...

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PMID: 19640989
DOI: 10.1128/jvi.00589-09

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