Article
Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis.
Journal of clinical periodontology - 1 Sept 2004
Itagaki Manami, Kubota Takehiko, Tai Hideaki, Shimada Yasuko, Morozumi Toshiya, Yamazaki Kazuhisa
Abstract excerpt
BACKGROUND/AIMS: Matrix metalloproteinase (MMP)-1 and MMP-3 have important roles in the connective tissue remodelling and destruction processes in periodontitis. MMP-1 1G/2G (-1607) and MMP-3 5A/6A (-1171) polymorphisms have been identified and appear to influence the transcription of the genes. The aim of this study was to investigate whether these gene promoter polymorphisms were associated with the...
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