Article
Membrano-proliferative glomerulonephritis, atypical hemolytic uremic syndrome, and a new complement factor H mutation: report of a case.
Pediatric nephrology (Berlin, Germany) - 1 Oct 2012
Gnappi Elisa, Allinovi Marco, Vaglio Augusto, Bresin Elena, Sorosina Annalisa, Pilato Francesco P, Allegri Landino, Manenti Lucio
Abstract excerpt
BACKGROUND: Complement protein factor H (CFH) is a regulatory protein of the alternative complement pathway (AP); CFH mutations lead to a spectrum of different phenotypical manifestations of renal disease. CASE-DIAGNOSIS/TREATMENT: We report the case of a boy with a novel CFH gene mutation who presented with a membranoproliferative (MPGN) pattern of glomerular injury and developed 2 years later atypical hemolytic...
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