Modeling of globular proteins. A distance-based data search procedure for the construction of insertion/deletion regions and Pro----non-Pro mutations.

Abstract excerpt

A distance-based database search scheme is proposed for modeling Pro----in non-Pro and insertion/deletion regions of homologous globular proteins up to six residues in length. In the first step, geometric descriptors, the number of residues involved and target distances corresponding to the separation of C alpha atom positions adjacent to the "missing" segment, are chosen. In the second step, a database of...

Topics

• Algorithms
• Amino Acid Sequence
• Aspartic Acid Endopeptidases
• Chymotrypsin
• Crystallography
• Dipeptides
• Hydrogen Bonding
• Models, Molecular
• Models, Structural
• Molecular Sequence Data
• Molecular Structure