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Article

Cardiac explant-derived cells are regulated by Notch-modulated mesenchymal transition.

PloS one - 1 Jan 2012

Zakharova Liudmila, Nural-Guvener Hikmet, Gaballa Mohamed A

Abstract excerpt

BACKGROUND: Progenitor cell therapy is emerging as a novel treatment for heart failure. However the molecular mechanisms regulating the generation of cardiac progenitor cells is not fully understood. We hypothesized that cardiac progenitor cells are generated from cardiac explant via a process similar to epithelial to mesenchymal transition (EMT). METHODS/FINDINGS: Explant-derived cells were generated from...

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Identifiers

PMID: 22662227
DOI: 10.1371/journal.pone.0037800
PMCID: PMC3360598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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