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Article

Analysis of the first polar body: preconception genetic diagnosis.

Human reproduction (Oxford, England) - 1 Oct 1990

Verlinsky Y, Ginsberg N, Lifchez A, Valle J, Moise J, Strom C M

Abstract excerpt

In women who are heterozygous for a genetic disease, genetic analysis of the first polar body allows the identification of oocytes that contain the maternal unaffected gene. These oocytes can be fertilized and transferred to the mother without risk of establishing a pregnancy with a genetically abnormal embryo. We have demonstrated that removal of the first polar body has no effect on subsequent fertilization...

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Identifiers

PMID: 2266156
DOI: 10.1093/oxfordjournals.humrep.a137192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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