Article
Analysis of the first polar body: preconception genetic diagnosis.
Human reproduction (Oxford, England) - 1 Oct 1990
Verlinsky Y, Ginsberg N, Lifchez A, Valle J, Moise J, Strom C M
Abstract excerpt
In women who are heterozygous for a genetic disease, genetic analysis of the first polar body allows the identification of oocytes that contain the maternal unaffected gene. These oocytes can be fertilized and transferred to the mother without risk of establishing a pregnancy with a genetically abnormal embryo. We have demonstrated that removal of the first polar body has no effect on subsequent fertilization...
Topics
- Base Sequence
- DNA
- DNA Probes
- Fertilization in Vitro
- Genetic Diseases, Inborn
- Genotype
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Oocytes
- Polymerase Chain Reaction