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Article

Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Dec 2012

Hamada Nobuyuki, Imamura Yutaka, Hara Koyu, Kashiwagi Takahito, Imamura Yoshihiro, Nakazono Yoko, Chijiwa Katsumi, Watanabe Hiroshi

Abstract excerpt

The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term administration of oseltamivir. Intrahost variation of the virus showed that the H275Y mutant virus was the predominant...

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Source

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Identifiers

PMID: 22661221
DOI: 10.1007/s10156-012-0429-0
PMCID: PMC7101931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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