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Monitoring and characterization of oseltamivir-resistant pandemic (H1N1) 2009 virus, Japan, 2009-2010.

Emerging infectious diseases - 1 Mar 2011

Ujike Makoto, Ejima Miho, Anraku Akane, Shimabukuro Kozue, Obuchi Masatsugu, Kishida Noriko, Hong Xu, Takashita Emi, Fujisaki Seiichiro, Yamashita Kazuyo, Horikawa Hiroshi, Kato Yumiko, Oguchi Akio, Fujita Nobuyuki, Tashiro Masato, Odagiri Takato

Abstract excerpt

To monitor and characterize oseltamivir-resistant (OR) pandemic (H1N1) 2009 virus with the H275Y mutation, we analyzed 4,307 clinical specimens from Japan by neuraminidase (NA) sequencing or inhibition assay; 61 OR pandemic (H1N1) 2009 viruses were detected. NA inhibition assay and M2 sequencing indicated that OR pandemic (H1N1) 2009 virus was resistant to M2 inhibitors, but sensitive to zanamivir. Full-genome...

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Identifiers

PMID: 21392439
DOI: 10.3201/eid1703.101188
PMCID: PMC3166015

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