Article
Polymorphism 677C → T MTHFR gene in Mexican mothers of children with complex congenital heart disease.
Pediatric cardiology - 1 Jan 2013
Balderrábano-Saucedo Norma A, Sánchez-Urbina Rocio, Sierra-Ramírez José A, García-Hernández Normand, Sánchez-Boiso Adriana, Klunder-Klunder Miguel, Arenas-Aranda Diego, Bravo-Hernández Gabriela, Noriega-Zapata Penelope, Vizcaíno-Alarcón Alfredo
Abstract excerpt
Congenital heart defects (CHD) are the third leading cause of death in children <1 year of age in Mexico where there is a high prevalence of the 677C → T polymorphism of the MTHFR gene. This is important because the homozygous 677T/T MTHFR gene and deficiency of folic acid (FA) intake have been associated with CHD. Our objective was to analyze the possible association between the genotype 677T/T of the MTHFR gene...
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