Article
The influence of collagen-glycosaminoglycan scaffold relative density and microstructural anisotropy on tenocyte bioactivity and transcriptomic stability.
Journal of the mechanical behavior of biomedical materials - 1 Jul 2012
Caliari Steven R, Weisgerber Daniel W, Ramirez Manuel A, Kelkhoff Douglas O, Harley Brendan A C
Abstract excerpt
Biomaterials for orthopedic tissue engineering must balance mechanical and bioactivity concerns. This work describes the fabrication of a homologous series of anisotropic collagen-GAG (CG) scaffolds with aligned tracks of ellipsoidal pores but increasing relative densities (ρ(∗)/ρ(s)), and we report the role scaffold relative density plays in directing tenocyte bioactivity. Scaffold permeability and mechanical...
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