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Article

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts.

Neurotoxicology - 1 Aug 2012

van Thriel Christoph, Westerink Remco H S, Beste Christian, Bale Ambuja S, Lein Pamela J, Leist Marcel

Abstract excerpt

The developing nervous system is particularly vulnerable to chemical insults. Exposure to chemicals can result in neurobehavioural alterations, and these have been used as sensitive readouts to assess neurotoxicity in animals and man. Deconstructing neurobehaviour into relevant cellular and molecular components may allow for detection of specific neurotoxic effects in cell-based systems, which in turn may allow...

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Identifiers

PMID: 22008243
DOI: 10.1016/j.neuro.2011.10.002
PMCID: PMC3288589

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