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Article

Patients with inflammatory bowel disease exhibit dysregulated responses to microbial DNA.

PloS one - 1 Jan 2012

Hotte Naomi S C, Salim Saad Y, Tso Robert H, Albert Eric J, Bach Phil, Walker John, Dieleman Levinus A, Fedorak Richard N, Madsen Karen L

Abstract excerpt

BACKGROUND: A critical role for the gut epithelium lies in its ability to discriminate between pathogens and commensals and respond appropriately. Dysfunctional interactions between microbes and epithelia are believed to have a role in inflammatory bowel disease (IBD). In this study, we analyzed microbiota and gene expression in IBD patients and examined responses of mucosal biopsies to bacterial DNA. METHODS:...

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Identifiers

PMID: 22649567
DOI: 10.1371/journal.pone.0037932
PMCID: PMC3359330

Genes

NOD2
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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