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Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

23 Mar 2020

Abstract excerpt

Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and non-inflamed colonic mucosa [50 Crohn's disease (CD); 80 ulcerative colitis (UC); 31 controls]. Changes in community-wide and within-patient microbiota are linked with inflammation, but we find no...

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PMID: 32251296
DOI: 10.1038/s41467-020-15342-5

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