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Article

Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 May 2012

Zenker Jennifer, Poirot Olivier, de Preux Charles Anne-Sophie, Arnaud Estelle, Médard Jean-Jacques, Lacroix Catherine, Kuntzer Thierry, Chrast Roman

Abstract excerpt

Peripheral nerve hyperexcitability (PNH) is one of the distal peripheral neuropathy phenotypes often present in patients affected by type 2 diabetes mellitus (T2DM). Through in vivo and ex vivo electrophysiological recordings in db/db mice, a model of T2DM, we observed that, in addition to reduced nerve conduction velocity, db/db mice also develop PNH. By using pharmacological inhibitors, we demonstrated that the...

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Identifiers

PMID: 22649228
DOI: 10.1523/JNEUROSCI.0719-12.2012
PMCID: PMC6703576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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