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Article

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

Science signaling - 29 May 2012

Xu Chao, Jin Jing, Bian Chuanbing, Lam Robert, Tian Ruijun, Weist Ryan, You Linya, Nie Jianyun, Bochkarev Alexey, Tempel Wolfram, Tan Chris S, Wasney Gregory A, Vedadi Masoud, Gish Gerald D, Arrowsmith Cheryl H, Pawson Tony, Yang Xiang-Jiao, Min Jinrong

Abstract excerpt

Ankyrin repeat family A protein 2 (ANKRA2) interacts with the plasma membrane receptor megalin and the class IIa histone deacetylases HDAC4 and HDAC5. We report that the ankyrin repeat domains of ANKRA2 and its close paralog regulatory factor X-associated ankyrin-containing protein (RFXANK) recog...

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Source

Identifiers

PMID: 22649097
DOI: 10.1126/scisignal.2002979

Genes

HDAC4
HDAC5
HDAC9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22649097-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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