Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bypassing the Greatwall-Endosulfine pathway: plasticity of a pivotal cell-cycle regulatory module in Drosophila melanogaster and Caenorhabditis elegans.

Genetics - 1 Aug 2012

Kim Min-Young, Bucciarelli Elisabetta, Morton Diane G, Williams Byron C, Blake-Hodek Kristina, Pellacani Claudia, Von Stetina Jessica R, Hu Xiaoqian, Somma Maria Patrizia, Drummond-Barbosa Daniela, Goldberg Michael L

Abstract excerpt

In vertebrates, mitotic and meiotic M phase is facilitated by the kinase Greatwall (Gwl), which phosphorylates a conserved sequence in the effector Endosulfine (Endos). Phosphorylated Endos inactivates the phosphatase PP2A/B55 to stabilize M-phase-specific phosphorylations added to many proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Carboxylic Ester Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Order

Share to Intercellular Signaling Peptides and Proteins

Share to Meiosis

Share to Mitosis

Share to Phosphoprotein Phosphatases

Share to Protein Subunits

Source

Open in PubMed Open full text

Identifiers

PMID: 22649080
DOI: 10.1534/genetics.112.140574
PMCID: PMC3416000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22649080-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bypassing the Greatwall-Endosulfine pathway: plasticity of a pivotal cell-cycle regulatory module in Drosophila melanogaster and Caenorhabditis elegans.PMID 22649080Read ↗

Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis.Semantic proximity Read ↗

Greatwall-Endos-PP2A/B55Twins network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition.Semantic proximity Read ↗

alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila.Semantic proximity Read ↗

PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos.Semantic proximity Read ↗

The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system.Semantic proximity Read ↗

Cyclin E and Cdk2 Control GLD-1, the Mitosis/Meiosis Decision, and Germline Stem Cells in Caenorhabditis elegansSemantic proximity Read ↗

The DSL ligand APX-1 is required for normal ovulation in C. elegans.Semantic proximity Read ↗

The C.elegans MAPK phosphatase LIP-1 is required for the G(2)/M meiotic arrest of developing oocytes.Semantic proximity Read ↗

MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cellsSemantic proximity Read ↗

Co-expressed Cyclin D variants cooperate to regulate proliferation of germline nuclei in a syncytium.Semantic proximity Read ↗

Dominant mutations in the Caenorhabditis elegans Myt1 ortholog wee-1.3 reveal a novel domain that controls M-phase entry during spermatogenesis.Semantic proximity Read ↗

Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germlineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.