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Article

Cytochrome c oxidase-intermediate fibres: importance in understanding the pathogenesis and treatment of mitochondrial myopathy.

Neuromuscular disorders : NMD - 1 Aug 2012

Murphy Julie L, Ratnaike Thiloka E, Shang Ersong, Falkous Gavin, Blakely Emma L, Alston Charlotte L, Taivassalo Tanja, Haller Ronald G, Taylor Robert W, Turnbull Doug M

Abstract excerpt

An important diagnostic muscle biopsy finding in patients with mitochondrial DNA disease is the presence of respiratory-chain deficient fibres. These fibres are detected as cytochrome c oxidase-deficient following a sequential cytochrome c oxidase-succinate dehydrogenase reaction, often in a mosaic pattern within a population of cytochrome c oxidase-normal fibres. Detailed analysis of muscle biopsies from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22647770
DOI: 10.1016/j.nmd.2012.04.003
PMCID: PMC3476534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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