Article
Mitochondrial encephalomyopathies and cytochrome c oxidase deficiency: muscle culture study.
Acta neuropathologica - 1 Jan 1991
Nonaka I, Koga Y, Kikuchi A, Goto Y
Abstract excerpt
The populations of cytochrome c oxidase (CCO)-positive and -negative mitochondria were analyzed in the elongated cells containing occasional multiple nuclei (myotubes) in primary muscle cultures derived from patients with various forms of mitochondrial encephalomyopathies with CCO deficiency. Even in control muscle cultures, CCO-positive (79.7%) and -negative (20.3%) mitochondria were distributed randomly,...
Topics
- Adolescent
- Child
- Child, Preschool
- Culture Techniques
- Cytochrome-c Oxidase Deficiency
- Encephalomyelitis
- Epilepsies, Myoclonic
- Female
- Histocytochemistry
- Humans
- Infant
- Leigh Disease